T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Obradovic, Aleksandar; Dallos, Matthew; Zahurak, Marianna; Partin, Alan; Schaeffer, Edward; Ross, Ashley; Allaf, Mohamad; Nirschl, Thomas; Liu, David; Chapman, Carolyn; O'Neal, Tanya; Cao, Haiyi; Durham, Jennifer; Guner, Gunes; Baena-Del Valle, Javier; Ertunc, Onur; De Marzo, Angelo; Antonarakis, Emmanuel; Drake, Charles

doi:10.1158/1078-0432.ccr-19-3372

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

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Obradovic A. Z., Dallos M. C., Zahurak M. L., Partin A. W., Schaeffer E. M., Ross A. E., ...More

CLINICAL CANCER RESEARCH, vol.26, no.13, pp.3182-3192, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 26 Issue: 13
Publication Date: 2020
Doi Number: 10.1158/1078-0432.ccr-19-3372
Journal Name: CLINICAL CANCER RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, EMBASE, Gender Studies Database, MEDLINE
Page Numbers: pp.3182-3192
Süleyman Demirel University Affiliated: Yes

Abstract

Purpose: Previous studies suggest that androgen deprivation therapy (ADT) promotes antitumor immunity in prostate cancer. Whether a vaccine-based approach can augment this effect remains unknown.