T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Obradovic, Aleksandar; Dallos, Matthew; Zahurak, Marianna; Partin, Alan; Schaeffer, Edward; Ross, Ashley; Allaf, Mohamad; Nirschl, Thomas; Liu, David; Chapman, Carolyn; O'Neal, Tanya; Cao, Haiyi; Durham, Jennifer; Guner, Gunes; Baena-Del Valle, Javier; Ertunc, Onur; De Marzo, Angelo; Antonarakis, Emmanuel; Drake, Charles

doi:10.1158/1078-0432.ccr-19-3372

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Obradovic A. Z. , Dallos M. C. , Zahurak M. L. , Partin A. W. , Schaeffer E. M. , Ross A. E. , ...More

CLINICAL CANCER RESEARCH, vol.26, no.13, pp.3182-3192, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 26 Issue: 13
Publication Date: 2020
Doi Number: 10.1158/1078-0432.ccr-19-3372
Title of Journal : CLINICAL CANCER RESEARCH
Page Numbers: pp.3182-3192

Abstract

Purpose: Previous studies suggest that androgen deprivation therapy (ADT) promotes antitumor immunity in prostate cancer. Whether a vaccine-based approach can augment this effect remains unknown.