Effects of dietary long chain PUFAs on hippocampal lipid peroxidation and NMDA receptor subunits A and B concentration in streptozotocin-diabetic rats
INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.114, no.10, pp.1353-1366, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 114 Issue: 10
- Publication Date: 2004
- Doi Number: 10.1080/00207450490476147
- Journal Name: INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1353-1366
- Süleyman Demirel University Affiliated: No
Abstract
This study examined the effects of streptozotocin (STZ)-diabetes and dietary long chain polyunsaturated fatty acids (LC-PUFAs) on hippocampal N-methyl-D-aspartate (NMDA) receptor subunit expression and lipid peroxidation. MDA level was significantly increased after 8 weeks of STZ-diabetes. LC-PUFAs administration significantly reduced MDA levels in diabetic rats. NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats. Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats. Consequently, dietary LC-PUFAs can partially restore hippocampal NMDA receptors and decrease lipid peroxidation in diabetes. LC-PUFAs arc thus a possible prophylactic means for preventing the cognitive deficiencies of diabetes.