SYNTHESIS AND ANTICANCER ACTIVITY OF 5- CHLORO-3-((6-CHLORO- [1,2,4]TRIAZOLO[4,3- b]PYRIDAZIN-3-YL)METHYL)BENZO[d]THIAZOL- 2(3H)- ONE

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Akdağ M., Arslan G., Oruç H., Özçelik A. B.

International Multidisciplinary Symposium on Drug Research and Development - DRD 2023, İzmir, Turkey, 6 - 08 May 2023, pp.174, (Full Text)

  • Publication Type: Conference Paper / Full Text
  • City: İzmir
  • Country: Turkey
  • Page Numbers: pp.174
  • Süleyman Demirel University Affiliated: Yes

Abstract

Breast cancer is the most common cause of cancer cases among women worldwide estimated to cause 1 million deaths in 2040 [1]. Heterocycles are important building blocks of anticancer agents [2]. Of the aromatic heterocycle compounds, it has been widely reported that nitrogenbased heterocycles and benzothiazole derivatives have anticancer properties [2-4]. In this study, benzothiazol-2(3H)-one and [1,2,4]triazolo[4,3-b]pyridazine cores were merged and 5- chloro-3-((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)benzo[d]thiazol-2(3H)-one compound was designed. The compound was synthesized by both conventional and microwave irradiation methods. It was evaluated against MCF-7 breast cancer cells