QCM-DNA biosensor based on plasma modified PT/TiO2 nanocomposites

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Maslakci N., DANAS F. D., OKSUZ A. U.

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, vol.53, no.5, pp.311-316, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 53 Issue: 5
• Publication Date: 2016
• Doi Number: 10.1080/10601325.2016.1151651
• Journal Name: JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.311-316
• Süleyman Demirel University Affiliated: Yes

Abstract

A quartz crystal microbalance DNA biosensor based on plasma prepared polythiophene /titanium dioxide (PT/TiO2) nanocomposite was developed for the detection of genetically modified organisms (GMOs). DNA hybridization was studied by quartz crystal microbalance (QCM) and cyclic voltammetry (CV) measurements. Single stranded DNA probes were immobilized on the PT/TiO2 coated quartz crystal electrode and the hybridization between the immobilized probe and the target complementary sequence in solution was monitored. The developed QCM-DNA biosensor represented promising results for a real-time, label-free, direct detection of DNA samples for the screening of genetically modified organisms.