Oxidative Stress Status Increase in Patients with Nonischemic Heart Failure

Karabacak M., Dogan A., Tayyar S., Bas H. A.

MEDICAL PRINCIPLES AND PRACTICE, vol.23, no.6, pp.532-537, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1159/000365512
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.532-537
  • Süleyman Demirel University Affiliated: Yes


Objective: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). Subjects and Methods: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York Heart Association class III). The patients had a left ventricular (LV) ejection fraction (EF) of <= 40% and normal coronary arteries or nonsignificant stenosis (stenosis <40%). In addition, 30 age- and sex-matched normal patients were selected as the control group. Clinical and laboratory characteristics presumed to be associated with oxidative stress were evaluated. Results: Demographic characteristics were comparable. However, creatinine and potassium levels were higher in the HF than in the control group. Total oxidative status [2.42 mu mol H2O2 Eq/l (range 0.74-5.86) vs. 1.81 mu mol H2O2 Eq/l (range 0.42-3.45); p < 0.01], oxidative stress index [2.24 (range 0.63-5.33) vs. 1.53 (range 0.28-2.51); p < 0.01] and uric acid (6.1 +/- 1.8 vs. 4.4 +/- 1.1 mg/dl; p < 0.01) levels were significantly higher in the HF than in the control group. The total antioxidant capacity was similar in both groups [1.22 mmol Trolox Eq/l (range 0.61-1.99) vs. 1.18 mmol Trolox Eq/l (range 0.82-1.80); p = 0.77]. The gamma-glutamyltransferase levels were also comparable in both groups [32 U/l (range 11-106) vs. 23 U/l (range 11-72); p = 0.10]. Conclusion: The oxidative stress levels were higher in HF patients, and hence, oxidative stress may play an important role in poor prognosis of HF. Therefore, antioxidant treatment might be reasonable. (C) 2014 S. Karger AG, Basel