Synthesis and characterization of new 4,5-dihydropyrazol-1-yl derivatives


Guney F. O. , İLHAN İ. Ö. , AKKOÇ S.

SYNTHETIC COMMUNICATIONS, vol.49, no.18, pp.2417-2424, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 18
  • Publication Date: 2019
  • Doi Number: 10.1080/00397911.2019.1627457
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.2417-2424

Abstract

In this study, first, a series of chalcone compounds S1-S6 were synthesized from various acetophenone derivatives (acetophenone, p-methyl acetophenone, and p-methoxy acetophenone) and aromatic aldehyde derivatives (benzaldehyde, p-methyl benzaldehyde, and p-methoxy benzaldehyde) by the Claisen-Schmidt condensation reaction. These S1-S6 compounds were then used in the preparation of 4,5-dihydropyrazol-1-yl derivatives S7-S15. Finally, four new compounds S16-S19 were synthesized from compound (S7, S8, S9, and S12) and 2,4-dinitrophenylhydrazine. Therefore, three known and ten new heterocyclic compounds were synthesized and completely characterized using H-1 NMR, C-13 NMR, IR, and elemental analysis.