Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model
TOXICOLOGY MECHANISMS AND METHODS, cilt.33, sa.6, ss.480-489, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 6
- Basım Tarihi: 2023
- Doi Numarası: 10.1080/15376516.2023.2187729
- Dergi Adı: TOXICOLOGY MECHANISMS AND METHODS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.480-489
- Anahtar Kelimeler: Curcumin, inflammatory bowel disease, intestinal permeability, ulcerative colitis, vitamin D, INFLAMMATORY-BOWEL-DISEASE, OXIDATIVE STRESS, DOUBLE-BLIND, ANTIOXIDANT, CYTOKINES, INCREASE, OCCLUDIN, MENTHOL, ZONULIN, INJURY
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Ulcerative Colitis (UC) is a disease that negatively affects quality of life and is associated with sustained oxidative stress, inflammation and intestinal permeability. Vitamin D and Curcumin; It has pharmacological properties beneficial to health, including antioxidant and anti-inflammatory properties. Our study investigates the role of Vitamin D and Curcumin in acetic acid-induced acute colitis model. To investigate the effect of Vitamin D and Curcumin, Wistar-albino rats were given 0.4 mcg/kg Vitamin D (Post-Vit D, Pre-Vit D) and 200 mg/kg Curcumin (Post-Cur, Pre-Cur) for 7 days and acetic acid was injected into all rats except the control group. Our results; colon tissue TNF-alpha, IL-1 beta, IL-6, IFN-gamma and MPO levels were found significantly higher and Occludin levels were found significantly lower in the colitis group compared to the control group (p < 0.05). TNF-alpha and IFN-gamma levels decreased and Occludin levels increased in colon tissue of Post-Vit D group compared to colitis group (p < 0.05). IL-1 beta, IL-6 and IFN-gamma levels were decreased in colon tissue of Post-Cur and Pre-Cur groups (p < 0.05). MPO levels in colon tissue decreased in all treatment groups (p < 0.05). Vitamin D and Curcumin treatment significantly reduced inflammation and restored the normal histoarchitecture of the colon. From the present study findings, we can conclude that Vitamin D and Curcumin protect the colon from acetic acid toxicity with their antioxidant and anti-inflammatory potential.Brief synopsis: In this study; distal colon, distal ileum, jejunum and serum physiopathology in colitis induced by acetic acid and intestinal permeability were investigated. The roles of vitamin D and curcumin in this process were evaluated.