Circulating miR-29c-3p is downregulated in patients with acromegaly
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.4, ss.2081-2086, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.3906/sag-2010-245
- Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.2081-2086
- Anahtar Kelimeler: Acromegaly, miR-29c-3p, miR-31-5p, miR-18a-5p, MICRORNAS, EXPRESSION
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
Background/aim: miRNAs control various biological functions, such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGP-1 gene were determined by in silico estimation.