Circulating miR-29c-3p is downregulated in patients with acromegaly


KORKMAZ H. , HEKİMLER ÖZTÜRK K. , Torus B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.4, pp.2081-2086, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2010-245
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.2081-2086
  • Keywords: Acromegaly, miR-29c-3p, miR-31-5p, miR-18a-5p, MICRORNAS, EXPRESSION

Abstract

Background/aim: miRNAs control various biological functions, such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGP-1 gene were determined by in silico estimation.