Copyright © Società Editrice Universo (SEU)Parvovirus B19 infection can be associated with a wide spectrum of clinical manifestations that mainly depends on the clinical background of the patient. Infection causes severe aplastic effects on bone marrow in immunosuppressive patients. Our patient was using Azathioprine for Crohn Disease when she admitted with malaise and fatigue laboratory tests revealed pancytopenia due to Parvovirus B19 infection. But contrary to expectations patients pancytopenia improved spontaneously without any treatment. Although intravenous immunoglobulin treatment is a safe approach waiting spontaneous recovery of bone marrow may be risky but another option.