Amplification of cellular oncogenes in solid tumors


Bagci O., Kurtgoz S.

NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, vol.7, no.8, pp.341-346, 2015 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 7 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.4103/1947-2714.163641
  • Title of Journal : NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.341-346

Abstract

The term gene amplification refers to an increase in copy number of a gene. Upregulation of gene expression through amplification is a general mechanism to increase gene dosage. Oncogene amplifications have been shown in solid human cancers and they are often associated with progression of cancer. Defining oncogene amplification is useful since it is used as a prognostic marker in clinical oncology nowadays, especially v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) targeted agents are used in breast cancer patients with high level of HER2 overexpression as a therapeutic approach. However, patients without HER2 overexpression do not appear to benefit from these agents. We concluded that determination of oncogene amplification in solid tumors is an important factor in treatment of human cancers with many unknowns. We have referred to PubMed and some databases to prepare this article.