Vascular wall damage in rats induced by organophosphorus insecticide methidathion

Yavuz T., Delibas N., Yildirim B., Altuntas I., Candir O., Cora A., ...More

TOXICOLOGY LETTERS, vol.155, no.1, pp.59-64, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 155 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.toxlet.2004.08.012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.59-64
  • Süleyman Demirel University Affiliated: No


We have examined the effect of subchronic methidathion (MD) administration on vascular wall damage. The experimental groups were: control group and rats treated with 5 mg/kg MD. The MD group was given MD by gavage for 5 days a week for 4 weeks at a dose level of 5 mg/kg per day by using corn oil as the vehicle. The levels of malondialdehyde (MDA) were determined in the vascular tissue. Histopathological examination was examined in-the thoracic aortic tissue. The levels of MDA were increased in the MD group compared with the control group (P <0.01). In the MD group, subchronic MD administration led to the irregulation, prominent breaks and fragmentation of the elastic fibers were located in the media of aortic wall.