New coumarin derivatives as carbonic anhydrase inhibitors

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KARATAŞ M. O., ALICI B., Cakir U., Cetinkaya E., Demir D., Ergun A., ...Daha Fazla

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.42, sa.3, ss.192-198, 2014 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 42 Sayı: 3
• Basım Tarihi: 2014
• Doi Numarası: 10.3109/21691401.2013.794352
• Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.192-198
• Süleyman Demirel Üniversitesi Adresli: Evet

Özet

In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others.