Letter to the Editor: Helicobacter pylori eradication in chronic aspirin users - a gastrointestinal strategy with cardiovascular implications?
World Journal of Gastroenterology, cilt.32, sa.37, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 37
- Basım Tarihi: 2026
- Doi Numarası: 10.3748/wjg.120403
- Dergi Adı: World Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Cardiovascular disease, Eradication therapy, Helicobacter pylori, Low-dose aspirin, Peptic ulcer bleeding
- Süleyman Demirel Üniversitesi Adresli: Evet
Özet
The prospective cohort study by Semeya et al provides important insights into the relationship among Helicobacter pylori (H. pylori) infection, peptic ulcer bleeding (PUB), and cardiovascular (CV) disease progression in chronic low-dose aspirin users. Persistent H. pylori infection was independently associated with increased risks of both PUB and short-term CV progression. Notably, successful eradication reduced the incidence of PUB from 11.9% to 3.7% and was associated with fewer CV events. Although the observational design limits causal inference, these findings suggest that H. pylori status may represent a modifiable factor in integrated gastrointestinal and CV risk management. Although randomized trials are needed, the data support considering H. pylori screening in selected high-risk aspirin users.