Synthesis, Characterization, and Antiproliferative Activity Studies of Novel Benzimidazole-Imidazopyridine Hybrids as DNA Groove Binders


Caymaz B., Yildiz U., AKKOÇ S., Gercek Z., Sengul A., Coban B.

CHEMISTRYSELECT, vol.5, no.28, pp.8465-8474, 2020 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 28
  • Publication Date: 2020
  • Doi Number: 10.1002/slct.202001580
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier
  • Page Numbers: pp.8465-8474
  • Keywords: Antiproliferative, Benzimidazole, Bis-benzimidazole, DNA cleavage, DNA groove binder, Electrophoresis, PERIPHERAL BENZODIAZEPINE-RECEPTORS, MINOR-GROOVE, ANTICANCER ACTIVITY, BIOLOGICAL EVALUATION, ANTITUMOR EVALUATION, CYTOTOXIC ACTIVITIES, SELECTIVE LIGANDS, BINDING-AFFINITY, DERIVATIVES, COMPLEXES

Abstract

A novel benzimidazole-imidazo[1,2-a]pyridine hybrid; 2-(imidazo[1,2-a]pyridine-8-yl)benzimidazole and its symmetrical bis- derivative 2,2 '-bis-(imidazo[1,2-a]pyridine-8-yl)-1H,1H '-[5,5 ']-bisbenzimidazole were synthesized and characterized. It was found that these two compounds have a strong DNA groove binding and peroxide mediated DNA-cleavage properties. Furthermore, these molecules were screened against three different human cell lines namely HepG2, DLD-1 and MDA-MB-231, and these compounds were found to have high cytotoxic activities.