CHEMISTRYSELECT, vol.5, no.28, pp.8465-8474, 2020 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus, Academic Search Premier
Antiproliferative, Benzimidazole, Bis-benzimidazole, DNA cleavage, DNA groove binder, Electrophoresis, PERIPHERAL BENZODIAZEPINE-RECEPTORS, MINOR-GROOVE, ANTICANCER ACTIVITY, BIOLOGICAL EVALUATION, ANTITUMOR EVALUATION, CYTOTOXIC ACTIVITIES, SELECTIVE LIGANDS, BINDING-AFFINITY, DERIVATIVES, COMPLEXES
A novel benzimidazole-imidazo[1,2-a]pyridine hybrid; 2-(imidazo[1,2-a]pyridine-8-yl)benzimidazole and its symmetrical bis- derivative 2,2 '-bis-(imidazo[1,2-a]pyridine-8-yl)-1H,1H '-[5,5 ']-bisbenzimidazole were synthesized and characterized. It was found that these two compounds have a strong DNA groove binding and peroxide mediated DNA-cleavage properties. Furthermore, these molecules were screened against three different human cell lines namely HepG2, DLD-1 and MDA-MB-231, and these compounds were found to have high cytotoxic activities.