Synthesis, Characterization, and Antiproliferative Activity Studies of Novel Benzimidazole-Imidazopyridine Hybrids as DNA Groove Binders

Caymaz B., Yildiz U., AKKOÇ S. , Gercek Z., Sengul A., Coban B.

CHEMISTRYSELECT, cilt.5, ss.8465-8474, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 5 Konu: 28
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/slct.202001580
  • Dergi Adı: CHEMISTRYSELECT
  • Sayfa Sayıları: ss.8465-8474

Özet

A novel benzimidazole-imidazo[1,2-a]pyridine hybrid; 2-(imidazo[1,2-a]pyridine-8-yl)benzimidazole and its symmetrical bis- derivative 2,2 '-bis-(imidazo[1,2-a]pyridine-8-yl)-1H,1H '-[5,5 ']-bisbenzimidazole were synthesized and characterized. It was found that these two compounds have a strong DNA groove binding and peroxide mediated DNA-cleavage properties. Furthermore, these molecules were screened against three different human cell lines namely HepG2, DLD-1 and MDA-MB-231, and these compounds were found to have high cytotoxic activities.