Deciphering nutritional interventions for podocyte structure and function


AFŞAR B. , ELSÜRER AFŞAR R. , Demiray A., Covic A., Kanbay M.

PHARMACOLOGICAL RESEARCH, vol.172, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 172
  • Publication Date: 2021
  • Doi Number: 10.1016/j.phrs.2021.105852
  • Title of Journal : PHARMACOLOGICAL RESEARCH
  • Keywords: Food, Foot process, Nutrition, Podocyte proteinuria, Slit diaphragm, ENDOPLASMIC-RETICULUM STRESS, SLIT DIAPHRAGM, DIABETIC-NEPHROPATHY, HIGH GLUCOSE, GLOMERULAR PODOCYTE, MOLECULAR-MECHANISMS, ACTIN CYTOSKELETON, PROTECTS PODOCYTES, OXIDATIVE STRESS, UP-REGULATION

Abstract

Despite increasing awareness and therapeutic options chronic kidney disease (CKD) is still and important health problem and glomerular diseases constitute and important percentage of CKD. Proteinuria/albuminuria is not just a marker; but it also plays a direct pathogenic role in renal disease progression of CKD. Glomerular filtration barrier (GFB) which consists of fenestrated endothelial cells, fused basal membrane and interdigitating podocyte foot process and filtration slits between foot process is the major barrier for proteinuria/albuminuria. Many glomerular diseases are characterized by disruption of GFB podocytes, foot process and slit diaphragm. Many proteinuric diseases are non-specifically targeted by therapeutic agents such as steroids and calcineurin inhibitors with systemic side effects. Thus, there is unmet need for more efficient and less toxic therapeutic options to treat glomerular diseases. In recent years, modification of dietary intake, has been gained to treat pathologic processes introducing the concept of 'food as a medicine'. The effect of various nutritional products on podocyte function and structure is also trending, especially in recent years. In the current review, we summarized the effect of nutritional interventions on podocyte function and structure.