The Golhisar (Burdur) plain which is located in the southwest of Turkey have 1505 km2 watershed area. Yesilbarak nappes, Lycian nappes and neo-autochtonous rock units including para-allochthonous and Quaternary units are outcropped in the investigation area. Groundwater supplied from alluvium, conglomerate and limestone units. General groundwater flow direction is towards to south of the plain. The elevation of the groundwater table and the depths of the groundwater from the ground surface in the plain were measured between and 960-1644 m 4-57.07 m, respectively. The hydrogeochemical evaluations were made using the quality and pollution analyses of groundwater in the Golhisar plain. Groundwaters are Mg-Ca-HCO3, Ca-Mg-HCO3 and Ca-HCO3 facies. The increase of Mg is originated from Cameli formation, Orhaniye formation and Marmaris peridotite related to water-rock interaction. The US salinity diagram, Wilcox diagram, residual sodium carbonate (RSC), permeability index (PI) and Magnesium hazard (MH) are used to assess the suitability of groundwater for agricultural purposes. Groundwaters are suitable for usage as irrigation water in the plain. Agricultural activity is most important pollution in the plain. Nitrate content is increased because of agricultural activity in the research area. In addition, heavy metal contents of groundwater such as Al, As, Cr, Cu, Fe, Mn and Pb were also investigated. The results of heavy metal contents were compared to Turkish drinking water standards (TSE-266) and World Health Organization (WHO) and not exceed the permissible limit values is determined.