MOLECULAR IMAGING AND RADIONUCLIDE THERAPY, vol.30, no.2, pp.93-100, 2021 (Peer-Reviewed Journal)
Article / Article
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
Emerging Sources Citation Index, Scopus, TR DİZİN (ULAKBİM)
Hypoxia-inducible factor-1 alpha, colorectal cancer, F-18-FDG/PET/CT, MTV, TLG, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, TUMOR ANGIOGENESIS, FACTOR 1-ALPHA, UNFAVORABLE PROGNOSIS, FACTOR-I, EXPRESSION, OVEREXPRESSION, QUANTIFICATION, METASTASIS, CARCINOMA
Objectives: Post-hypoxia hypoxia-inducible factor (HIF)-1 alpha activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1 alpha, the prognostic significance of HIF-1 alpha in CRC and its correlation with 18-fluorinefluorodeoxyglucose (F-18-FDG) uptake in positron emission tomography (PET) remain controversial. This study aims to investigate the association between F-18-FDG/PET parameters and HIF-1 alpha expression in CRC.