SPECTROMETRIC DETERMINATION OF LEVOFLOXACIN AND NORFLOXACIN IN TABLETS BY MULTIVARIATE CALIBRATION APPROACH


AKTAŞ A. H. , GOKSU S.

REVIEWS IN ANALYTICAL CHEMISTRY, vol.29, no.2, pp.81-91, 2010 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2010
  • Title of Journal : REVIEWS IN ANALYTICAL CHEMISTRY
  • Page Numbers: pp.81-91

Abstract

Three multivariate calibration-prediction techniques, classical least squares (CLS), inverse least squares (ILS) and partial least squares (PLS) were applied to the spectrometric multicomponent analysis of the drug containing levofloxacin (LEVO) and norfloxacin (NORF) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of LEVO and NORF were used to check the prediction ability of the CLS, ILS and PLS. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the two drugs.