Effect of Curcumin on Systemic T Helper 17 Cell Response; Gingival Expressions of Interleukin-17 and Retinoic Acid Receptor-Related Orphan Receptor gamma t; and Alveolar Bone Loss in Experimental Periodontitis

BAKIR B., Ay Z., BÜYÜKBAYRAM H. İ. , Doguc D. K. , BAYRAM D., Candan I. A. , ...More

JOURNAL OF PERIODONTOLOGY, vol.87, no.11, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 11
  • Publication Date: 2016
  • Doi Number: 10.1902/jop.2016.150722
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: Alveolar bone loss, curcumin, interleukin-17, interleukin-23, periodontitis, Th17, TH17 CELLS, ANTIINFLAMMATORY AGENT, IL-17, AUTOIMMUNE, DISEASE, LIGAND, SITES, BETA, DIFFERENTIATION, PROGRESSION


Background: Curcumin has anti-inflammatory and antioxidant effects and is reported to have many biologic activities. The current study examines effect of curcumin on: 1) systemic T helper 17 (Th17) cell response; 2) gingival expressions of interleukin (IL)-17 and retinoic acid receptor-related orphan receptor (ROR) gamma t; and 3) alveolar bone loss (ABL) in experimental periodontitis.