Comparison of Serum VEGF, IGF-1, and HIF-1 alpha Levels in Children with Autism Spectrum Disorder and Healthy Controls


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Şimşek F., Işık Ü. , Aktepe E., Kılıç F. , Şirin F. B. , Bozkurt M.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2021 (Journal Indexed in SSCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1007/s10803-020-04820-w
  • Title of Journal : JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS

Abstract

The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1 alpha levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1 alpha were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1 alpha levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1 alpha may play a potential role in the etiopathogenesis of ASD.