Introduction: This study aims to discuss cultural intelligence levels and intercultural communication apprehension of nurses. Method: This study was designed as a descriptive and cross-sectional study, and it was conducted with 252 nurses working in a hospital in a south city of Turkey. The research data were collected via a "Personal Information Form" designed by the researchers, "The Cultural Intelligence Scale," and "The Intercultural Communication Apprehension Scale." Results: It was concluded that nurses had moderate levels of cultural intelligence and intercultural communication apprehension, which were positively correlated (p < .001). Cultural intelligence levels and intercultural communication apprehension were further correlated with certain variables such as age, gender, job duration, foreign language proficiency, and their experiences in foreign countries (p < .05). Discussion: In light of the results, it was suggested that moderate levels of intercultural communication apprehension can be a supportive factor in developing cultural intelligence. It was also added that preventing excessive intercultural communication apprehension and supporting nurses to improve language skills and to have abroad experience may be beneficial in developing cultural intelligence.